Application of botulinum toxin in the treatment of rose acne

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The facial flushing of rose acne seriously affects the quality of life of patients, often causing anxiety and depression. It has recently been found that botulinum toxin microinjection can effectively alleviate facial flushing symptoms of rose acne.

The mechanism of action of botulinum toxin in the treatment of rose acne

Botox is a neurotoxin that was first used Coming to be a biochemical weapon, it was later used by the medical community to treat hemifacial spasm and wrinkles. Botulinum toxin type A achieves denervation by blocking the release of acetylcholine from presynaptic vesicles. The muscles do not shrink when they are not commanded by nerves, and thus can be used to treat diseases characterized by excessive muscle contraction, such as Strabismus, hernia, lateral paralysis and cervical dystonia. It was later discovered that botulinum toxin prevented the release of acetylcholine from the parasympathetic nerve endings, thus expanding its indications such as hyperhidrosis, periodic migraine, tension headache and myofascial pain. It has recently been discovered that botulinum toxin can also act on the sympathetic nerves of the skin, so that it can not release the excitatory signal, and the blood vessels of the facial skin can not be easily stimulated by the nerves, and thus no longer easily expand, thereby effectively alleviating the facial flushing symptoms of the rose acne.

Denervation mechanism of botulinum toxin

Botox treatment of rose acne can cause facial paralysis ?

The treatment of rose acne with botulinum toxin microinjection is usually 30-50U, and only injected into the dermis layer of 0.5-2mm, not diffused into the muscle layer, so Does not cause facial expression paralysis.

The limitations of botulinum toxin treatment of rose acne

The pathogenesis of acne is complex and botulinum toxin can act The goal of vascular neuromodulation is far from solving all the problems, so other treatments are still needed. Moreover, the metabolic time of botulinum toxin is 3-6 months, and repeated injections are required.

It is important to emphasize that the number of existing cases is still very limited, and the exact scope and safety require more clinical research.


J Drugs Dermatol. 2012;11(12):e76-9.

Dermatology. 2015;230(4):299-301.

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