Can the HPV vaccine not be played? Academician of the Chinese Academy of Engineering


How terrible is cervical cancer?

Tongji Hospital Obstetrics and Gynecology Oncologist Martin Academician said that the cervix Cancer is one of the most common gynaecological malignancies, and global data show that its mortality rate is gradually rising to the top of gynecological cancer. According to the statistics of the World Health Organization, there are nearly 500,000 new cases of cervical cancer every year, of which more than 100,000 new cases in China, accounting for about one-third of the world, the incidence rate has risen significantly and tends to be younger.


Infected HPV virus is equivalent to cervical cancer?

In 2008, German medical scientist and virologist Harald zur Hausen discovered the external cause of cervical cancer, the HPV virus, the human papillomavirus, which is mainly transmitted through sexually transmitted diseases. There are about 170 types of HPV viruses found, and the health risks of different types of HPV viruses vary, and about 14 of them are identified as high-risk HPV viruses.

Mr. Martin said that medical evidence has confirmed that the high-risk HPV virus persistent infection has increased the risk of cervical cancer by 300 times. However, infection with HPV does not mean cervical cancer. A large number of studies have shown that more than 70% of women have at least one HPV infection in their lifetime, but most HPV infections are naturally eliminated by the body’s own immune system, only about 1%. -4% of HPV-infected patients will gradually develop cervical precancerous lesions or cancerous changes, so cervical HPV infection is a “cold” of the cervix, which is an accidental incident of common infection.


After inoculation with HPV vaccine, you can rest easy?

French Academician: Currently, there are three types of HPV vaccines listed worldwide.

One ​​is a bivalent HPV vaccine that prevents HPV16 and HPV18-induced malignant tumors in the lower genital tract and perianal;

Second, the four-valent HPV vaccine can prevent the lower genital tract and perianal wetness caused by HPV6 and HPV11 in addition to the malignant tumors of the lower genital tract and perianal area induced by HPV16 and HPV18;

The third is the nine-valent HPV vaccine, which is mainly for HPV16, HPV18, HPV31, HPV33, HPV45, HPV52, HPV58-induced malignant tumors in the lower genital tract and perianal area, as well as HPV6. HPV11 can prevent the lower genital tract and perianal wetness caused by HPV6 and HPV11.

The current domestic market is the bivalent and tetravalent HPV vaccine.

Research data show that bivalent and tetravalent HPV vaccines can prevent about 70% of cervical cancer, and the coverage rate of nine-valent vaccine HPV is as high as 92%. The three vaccines were mainly designed and validated based on the epidemiological background of Western populations, and the proportion of protection against Asian populations was relatively lower than that of Westerners.

Even if inoculated with bivalent and tetravalent HPV vaccines, it does not completely cover all subtypes of high-risk HPV. In addition, vaccination with HPV is not a once and for all. In 2016, the famous Australian rowing athlete, Salad Tate, who had been vaccinated with HPV, died of cervical cancer at the age of 33.

Academician Martin stressed that even if a cervical cancer vaccine is given, regular cervical cancer screening should be done. Through physical examination, even if the high-risk HPV virus is infected, cervical precancerous lesions need to progress to cervical cancer after 8-10 years. In this window for cervical screening, the lesion can be blocked by simple and effective intervention. The possibility of developing cervical cancer. Therefore, the HPV vaccine is important, and regular cervical cancer screening is equally important.


Are you a high-risk group of cervical cancer?

Academician Martin said that the incidence of cervical cancer may be related to genetic susceptibility gene mutations. Since 2009, the team of Martin Fellows of the Obstetrics and Gynecology Department of Tongji Hospital took the lead in proposing the concept of accurate screening of cervical cancer susceptibility gene SNP mutations in the national population. Through a sample survey of 16,484 Chinese Han populations in 3 years, 11 new cervical cancer genetic susceptibility mutation sites were discovered.

Then, they collected the cervical cancer family in the country for analysis and analysis, and confirmed the genetic susceptibility of cervical cancer: HPV infection is only an external cause of cervical cancer, and the inherent hereditary nature is The root cause of the disease, for the first time in the world, unlocked the mystery of the genetic susceptibility of Chinese Han cervical cancer. In 2013, the research results were published in the international top professional journal Nature Genetics, with an impact factor of 35.8, which caused quite a stir in the field of cervical disease research worldwide.


How can the people be able to afford it?

Although the current HPV vaccine has been approved for use in 160 countries around the world, the safety of the vaccine has to be discussed. In the first half of 2013, more than 30 Japanese women were exposed to HPV vaccine and suffered from chest pain and other rare serious complications.

Academician Martin said that only 1%-4% of individuals will gradually develop into cervical precancerous lesions and cancerous, and for the incidence of less than 4%, the implementation of foreign vaccination in China The HPV vaccine is not practical.

Article source: Good doctor online, Sohu health, article views only represent the author himself

Image source: photo network



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