Scientists clarify the new mechanism of bacterial antibiotic resistance

A few days ago, a study published in the international magazine PNAS, scientists from the University of Montana, through research, revealed a new mechanism for the resistance of pathogens to antibiotic therapy.

Researcher Professor Patrick Secor said that antibiotic resistance is a public health problem facing the world today, and we found that it is taken from the patient’s infected lung tissue during the patient’s antibiotic therapy. After surviving bacteria, these bacteria are treated with the same antibiotics in the laboratory. These bacteria actually die, so what is the reason? In this study we want to clarify the reasons for this through research.

Researchers have found that polymers in the body’s tracheal mucus have a physical effect on bacterial cells; bacteria living in high-concentration polymer environments tend to feel some stress. Essentially, a polymer-rich environment activates the bacteria to produce a stress response that promotes bacterial tolerance to high concentrations of antibiotics. Professor Secor said, I really like to compare this situation with the stress we are taking when exercising. Every day exercise will let us run further, or can lift a heavier object, which is related to living in the tracheal mucosa. The stress response produced by bacteria is similar, and daily exposure to stress promotes the survival of bacteria under stress conditions in the later antibiotic environment.

The mucosal polymer physically affects the stress response of bacteria, which causes bacterial cells to produce mild DNA damage, and DNA damage slows the growth of bacteria; Targeting rapidly dividing bacterial cells that may not be effective in killing these slow-growing bacteria. Researchers speculate that the mechanism by which mucosal polymers initiate bacterial stress responses may be used to develop novel targeted therapies to treat long-term bacterial infections. Finally, researcher Secor said that in the future we hope to develop more effective treatments for bacterial infections or increase the effectiveness of current antibiotics through more in-depth research.

                

                
                                    

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